Topiramate Reduces Energy and Fat Gains in Lean (Fa/?) and Obese (fa/fa) Zucker Rats
نویسندگان
چکیده
منابع مشابه
Cytokine-induced fever in obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats.
In earlier work, we reported that genetically obese ( fa/ fa) Zucker rats exhibited significantly greater anorexia than did lean ( Fa/ Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1β. Here, we investigated the fever response of obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats to intracerebroventricular microinfusion of IL-1β as well as to the following other cytokines: ...
متن کاملImmuno-Modulator Metallo-Peptide Reduces Inflammatory State in Obese Zucker Fa/Fa Rats
Metabolic syndrome is a prothrombotic and proinflammatory chronic state. In obesity, the adipose tissue secretes various adipokines that take part in a variety of physiological and pathophysiological processes, including immunity and inflammation. Previous studies using a liver damage model treated with the immune-modulator metallo-peptide (IMMP) showed lessening in the degree of inflammation. ...
متن کاملLean ( Fa/ Fa) but not obese ( fa/ fa) Zucker rats release cholecystokinin at PVN after a gavaged meal.
Neuropeptides play an important role in the integration of dietary signals. Cholecystokinin (CCK) has been implicated in regulating ingestive behavior, particularly satiety. The primary objective of this study was to examine whether the hyperphagia characteristic of obese ( fa/ fa) rats involves impaired neural CCK secretion. Dynamic release of CCK at the hypothalamic paraventricular nucleus (P...
متن کاملSleeve gastrectomy reduces blood pressure in obese (fa/fa) Zucker rats.
BACKGROUND Sleeve gastrectomy constitutes an effective surgical procedure for the treatment of morbid obesity in humans and rodents with diet-induced obesity. The aim of the present study was to establish the effects of sleeve gastrectomy on weight loss and cardiovascular parameters in genetically obese (fa/fa) Zucker rats. METHODS Eleven-week-old male obese (fa/fa) (n = 20) Zucker rats were ...
متن کاملSoy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats.
Hepatic steatosis is commonly present during the development of insulin resistance, and it is a clear sign of lipotoxicity attributable in part to an accelerated lipogenesis. There is evidence that a soy protein diet prevents the overexpression of hepatic sterol-regulatory element binding protein-1 (SREBP-1), decreasing lipid accumulation. Therefore, the aim of the present work was to study whe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Obesity Research
سال: 2000
ISSN: 1071-7323
DOI: 10.1038/oby.2000.84